Induction of cytochrome promotes liver injury in ob/ob mice
نویسندگان
چکیده
منابع مشابه
In vivo induction of human cytochrome P450 enzymes expressed in chimeric mice with humanized liver.
The induction and inhibition of human cytochrome P450 (P450) enzymes are clinically responsible for drug interactions. Although the induction of P450s is investigated using human hepatocytes in the drug development process, there are some disadvantages, such as the decline of the enzyme activity during culture. In the present study, we examined the in vivo induction potency in chimeric mice wit...
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ژورنال
عنوان ژورنال: Hepatology
سال: 2007
ISSN: 0270-9139,1527-3350
DOI: 10.1002/hep.21603